Profile Comparer: a program for scoring and aligning profile hidden Markov models
نویسنده
چکیده
UNLABELLED Profile Comparer (PRC) is a stand-alone program for scoring and aligning profile hidden Markov models (HMMs) of protein families. PRC can read models produced by SAM and HMMER, two popular profile HMM packages, as well as PSI-BLAST checkpoint files. This application note provides a brief description of the profile-profile algorithm used by PRC. AVAILABILITY The C source code licensed under the GNU General Public Licence and Linux and Mac OS X binaries can be downloaded from http://supfam.org/PRC. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
منابع مشابه
webPRC: the Profile Comparer for alignment-based searching of public domain databases
Profile-profile methods are well suited to detect remote evolutionary relationships between protein families. Profile Comparer (PRC) is an existing stand-alone program for scoring and aligning hidden Markov models (HMMs), which are based on multiple sequence alignments. Since PRC compares profile HMMs instead of sequences, it can be used to find distant homologues. For this purpose, PRC is used...
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ورودعنوان ژورنال:
- Bioinformatics
دوره 24 شماره
صفحات -
تاریخ انتشار 2008